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Abstract #10076 Published in IGR 6-1
Lipid peroxidation in the pathogenesis of primary open-angle glaucoma
Ziangirova GG; Antonova OVVestnik Oftalmologii 2003; 119: 54-55
Nineteen tissue samples of the iris and trabecula if 17 patients, aged 49-79 years, with different stages of primary open-angle glaucoma (POAG), were examined to study the condition of lipid membranes in the iridial and trabecular tissues by electron microscopy. The results suggest that the key role, in the POAG pathogenesis, belongs to lipid peroxidation of the posterior and anterior leaves of the retinal pigment epithelium, which is an activator of the apoptotic processes in the trabecular endothelium. Therefore, it is advisable to use lipid- and water-soluble antioxidative drugs to correct the physiological antioxidative deficiency during complex POAG treatment. LA: Russian
Classification:
1.3 Pathogenesis (Part of: 1 General aspects)
