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Abstract #10143 Published in IGR 6-1
Hypotensive effect of unoprostone as adjunct to latanoprost during multiple drug therapy for glaucoma
Kobayashi H; Iwakiri R; Kobayashi K; Okinami SJapanese Journal of Clinical Ophthalmology 2004; 58: 193-197
PURPOSE: To evaluate the hypotensive effect of 0.012% unoprostone when added to latanoprost in multiple drug treatment. METHODS: Fifty eyes of 50 patients with primary open-angle glaucoma were enrolled in the study. They had been receiving 0.5% timolol, 0.005% latanoprost and 1% dorzolamide for three months or longer. They were randomly divided into two groups of 25 eyes each. One group received unoprostone adjunctively. The other continued the medication without unoprostone and served as a control. RESULTS: Baseline intraocular pressure (IOP) averaged 19.4 ± 2.5 mmHg in the unoprostone group and 19.6 ± 2.4 mmHg in the control group. There was no significant difference between the two values. Eight weeks after the start of unoprostone, IOP averaged 19.1 ± 1.9 mmHg in the unoprostone group and 19.6 ± 2.4 mmHg in the control group. There was no significant difference in IOP between both groups up to eight weeks. In 17 eyes with baseline IOP of 22 mmHg or over, the IOP decreased eight weeks later by 1.3 ± 1.0 mmHg in eight eyes receiving unoprostone and by 0.1 ± 1.0 mmHg in nine control eyes. This difference was significant (p = 0.0324). There was no difference in IOP in 33 eyes with baseline IOP of 21 mmHg or less. CONCLUSIONS: Addition of unoprostone did not induce further ocular hypotension when seen as a whole. Only when the baseline IOP was 22 mmHg or over did additional unoprostone induce significant IOP reduction. LA: Japanese
Dr. H. Kobayashi, Department of Ophthalmology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)