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Abstract #10426 Published in IGR 6-1
Mechanism of topiramate-induced acute-onset myopia and angle closure glaucoma
Craig JE; Ong TJ; Louis DL; Wells JMAmerican Journal of Ophthalmology 2004; 137: 193-195
DESIGN: Interventional case report. METHODS: In an institutional practice setting, two females, aged 25 and 45 years, developed acute myopia after starting topiramate for epilepsy. One patient also developed bilateral angle closure glaucoma. RESULTS: Topiramate was discontinued. Anterior chamber shallowing was noted in both patients at presentation. Ultrasonography showed ciliochoroidal effusion. Baseline measurements of anterior chamber depth and lens thickness were obtained. CONCLUSIONS: Topiramate may be associated with ciliochoroidal effusion with forward displacement of the lens-iris diaphragm and anterior chamber shallowing, resulting in acute myopia and angle-closure glaucoma. Increased lens thickness contributes only minimally (9-16%) to anterior chamber shallowing.
Dr. J.E. Craig, Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia. jamie.craig@flinders.edu.au
Classification:
9.3.1 Acute primary angle closure glaucoma (pupillary block) (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
