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(3)

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Abstract #10578 Published in IGR 6-2

The inhibitory effect of tranilast on transforming growth factor-β₂ expression in cultured human trabecular meshwork cells

Cao Y; Da BH; Wei HR
Chinese Journal of Ophthalmology 2004; 40: 254-7

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OBJECTIVE: To investigate the effect of tranilast on transforming growth factor-β₂ (TGF-β₂) expression in cultured human trabecular meshwork cells. METHODS: TGF-β₂ expression in cultured 3-5 passage human trabecular meshwork cells was measured by semi-quantitative RT-PCR after treated with 0.0 micro g/ml (control), 12.5, 25.0 and 50.0 mg/L tranilast for 48 h. RESULTS: The value of TGF-β₂/G3PDH of cells treated with 12.5, 25.0 and 50.0 mg/L tranilast was 1.85 ± 0.35, 1.66 ± 0.42, 1.16 ± 0.24, respectively. The difference between these treated groups and that of the control group (3.82 ± 0.56) was statistically significant (q' = 10.77, 11.80, 14.54, P < 0.01), respectively. The value of TGF-β₂/G3PDH in the tranilast treated trabecular meshwork cells decreased in a dose-dependent manner. CONCLUSION: Tranilast could inhibit TGF-β₂ expression in cultured human trabecular meshwork cells. It is worth to study the using of tranilast in the treatment of primary open-angle glaucoma. LA: Chinese

Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China ytsao@sohu.com

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Classification:

11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)

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