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Abstract #10737 Published in IGR 6-2
Effect of ocular perfusion pressure on microcirculation of human optic nerve head
Lu Y; Chu R; Sun X; Qian S; Meng FChinese Ophthalmic Research 2004; 22: 209-212
OBJECTIVE: To investigate the relationship between blood flow of the optic nerve head (ONHF) and ocular perfusion pressure in human. METHODS: Eight normal subjects, ten cases with primary open-angle glaucoma (POAG) and seven patients with normal tension glaucoma (NTC) from outpatient and inpatient clinic were recruited. The basic ONHFs of three groups were measured. Scleral suction was used to raise the IOP to 30 and 40 mmHg, and the ONHFs were measured with laser Doppler flowmetry. Then, the ONHFs at 1 and 5 min were measured after suction cup was removed. RESULTS: The difference of basic ONHF among the normal, POAG and NTG groups was not significant. When IOP raised to 30 mmHg, the ONHF kept steady in normal group but declined over 25% in POAG group, and decreased about 45% in NTG group. When IOP raised to 40 mmHg, the ONHF in normal group decreased about 30%, and over 50% and 65% in POAG and NTG group, respectively. One minute after the suction cup was removed, the ONHF increased about 31% in normal group and about 19% in POAG group, and no significantly increased in NTG group. Five minutes after the suction cup was removed, the ONHF in three groups was recovered. CONCLUSION: The microcirculation of optic nerve head in the normal group is autoregulated following perfusion pressure moderately decrease, but in POAG and NTG group, the autoregulation capacity become worse. LA: Chinese
Y. Lu, Eye and Ear Nose Throat Hospital, Fudan University, Shanghai 200031
Classification:
11.6 Osmotic treatment (Part of: 11 Medical treatment)
