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Abstract #10799 Published in IGR 6-2

The effect of substituting latanoprost 0.005% for unoprostone 0.12%

Otori Y; Tokugawa H; Morimura H; Okada M; Goto H; Miki A; Tano Y
Nippon Ganka Gakkai Zasshi 2004; 108: 207-12


PURPOSE: To evaluate the effect of substituting latanoprost(LAT) 0.005% for unoprostone(UNO) 0.12% after a trial of unilateral treatment. METHODS: We treated 30 patients with primary open-angle glaucoma(n = 8), ocular hypertension (n = 1), or normal-tension glaucoma(n = 21) with UNO for 4 weeks in one eye and then substituted LAT for UNO. Four weeks later we measured the intraocular pressure(IOP) in the ipsilateral eye. RESULTS: The mean baseline IOP level was 18.6 ± 3.8(mean ± standard deviation) mmHg. The mean IOP levels(reduction rates) after UNO and LAT therapy were 16.7 ± 3.1 mmHg (16.6%) and 14.1 ± 3.2 mmHg (28.9%), respectively(p < 0.001). All patients who responded to UNO also responded to LAT; however, 55% of those who did not respond to UNO responded to LAT. CONCLUSIONS: If LAT is substituted for UNO, it can be predicted that 63.3% of the patients will respond. LA: Japanese

Department of Ophthalmology and Visual Science, Osaka University Medical School, 2-2 Yamadaoka, Suita 565-0871, Japan.


Classification:

11.4 Prostaglandins (Part of: 11 Medical treatment)



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