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Abstract #11412 Published in IGR 6-3
Intraocular pressure lowering efficacy of travoprost
Przydryga JT; Egloff C; Swiss Start Study GroupEuropean Journal of Ophthalmology 2004; 14: 416-422
PURPOSE: To assess the intraocular pressure lowering effect of travoprost 0.004% in patients previously treated with another topical medication, and in previously untreated patients. METHODS: This 12-week, open-label trial in 1590 patients was conducted at 219 sites in Switzerland. Primary open-angle glaucoma and ocular hypertension patients discontinued prior medications, and instilled 1 drop of travoprost in each affected eye at 8 pm. Untreated patients were subdivided into 2 groups: baseline IOP of ≥ 21 mmHg, and baseline IOP of ≤ 20 mmHg. Patients returned for follow-up visits at 1 and 3 months. The primary outcome was mean IOP change from baseline to follow-up. RESULTS: Of 626 patients previously on monotherapy, and 525 previously untreated or newly-diagnosed patients, 479 and 423, respectively, completed 3 months of therapy. The mean changes from baseline at 1 month (mmHg ± SD), by prior treatment group were: beta blocker, -4.9 (± 3.6); latanoprost, -2.3 (± 2.8); alpha-agonist, -4.0 (± 3.7); dorzolamide/timolol fixed combination, -3.4 (± 3.9); topical CAI, -4.4 (± 3.1); new IOP ≥21 mmHg, -8.6 (± 4.4); new IOP ≤ 20 mmHg, -4.4 (± 3.0). (All changes from baseline were statistically significant (p < 0.0001). CONCLUSIONS: In patients previously treated with a single drug, travoprost decreased IOP to pressures below those achieved on prior therapy. In all groups, travoprost reduced mean IOP below 18 mmHg within 1 month of starting therapy, and control was maintained for at least 3 months. Overall, travoprost was safe and well-tolerated.
Dr. J.T. Przydryga, Alcon Laboratories, Inc., Fort Worth, TX, USA. Johan.Przydryga@AlconLabs.com
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
