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Abstract #11429 Published in IGR 6-3
Reaction of the physiological IOP in rabbits after application of the latanoprost (Xalatan) and amino acid L-arginin.HCl mixture
Veselovsky J; Olah Z; Vesela A; Gressnerova SČeska a Slovenska Oftalmologie 2004; 60: 319-327
Authors present results of series of experiments focused to influence the IOP by antiglaucomatics in rabbits (New Zealand White) with physiological IOP. Adding of the 10% amino acid L-arginin.HCl to the 0.005% Xalatan eye drops intensifies activity of antiglaucomatics resulting in 9.5% average reduction of the IOP in a four-hour experiments (with maximum in 15th min. - 19.3%), compared with application of both substances alone. Size of the pupil was not affected. Based on our experimental results we assume that the increased activity of the 0.005% Xalatan mixture with 10% amino acid L-arginin.HCl created a new complete metabolite - 'bio-antiglaucomaticum'. According to our observations this metabolite caused increase of the uveo-scleral outflow leading to the striking reduction of the physiological IOP in rabbits. LA: Slovak
Dr. J. Veselovsky, Kat. Zivocis. Fyziologie a Etologie, PriF UK, Mlynska Dolina B/2, 842 15 Bratislava, Slovakia
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)