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Abstract #11677 Published in IGR 7-1
Comparison of outcomes and predictors of trabeculectomy using high-dose or low-dose mitomycin C
Aquino MV; Lat Luna MML; Flores JVPDAsian Journal of Ophthalmology 2004; 6: 2-5
AIMS: To compare the outcomes of trabeculectomy using low-dose or high-dose mitomycin C and to determine the factors that predict the postoperative intraocular pressure. PATIENTS AND METHODS: In a prospective, randomised comparative study, patients undergoing trabeculectomy were randomly assigned to receive either mitomycin C 0.2 mg/mL for 4 minutes or mitomycin C 0.4 mg/mL for 2 minutes. The intraocular pressure, bleb character, and occurrence of complications were compared. Age and sex of the patients, preoperative intraocular pressure, mitomycin C concentration, bleb characteristics, angle status, and age of the surgery were analysed to determine whether they were predictive factors for postoperative intraocular pressure. RESULTS: Seventy four eyes of 68 patients at the Philippine General Hospital underwent trabeculectomy between January and June 1997. Thirty six eyes were treated with mitomycin C 0.2 mg/mL while 38 eyes were treated with mitomycin C 0.4 mg/mL. There were no statistically significant differences in the mean preoperative and postoperative intraocular pressures, and in the mean percent change in intraocular pressures between the 2 groups. Analysis of variance showed that preoperative intraocular pressure and bleb characteristics were significant predictors of postoperative intraocular pressure. CONCLUSIONS: There is no apparent difference in the outcomes of trabeculectomies using low-dose and high-dose mitomycin C. Preoperative intraocular pressure and bleb characteristics are predictive factors of postoperative intraocular pressure.
Prof. Dr. M.V. Aquino, Dept. of Ophthalmol./Visual Sciences, Philippine General Hospital, Taft Avenue, Ermita, Manila
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)