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Abstract #11949 Published in IGR 7-1
Apolipoprotein E promoter polymorphisms do not have a major influence on the risk of developing primary open angle glaucoma
Ressiniotis T; Griffiths PG; Birch M; Keers SM; Chinnery PFMolecular Vision 2004; 10: 805-807
PURPOSE: Primary open angle glaucoma (POAG) is a major cause of late onset visual failure of unknown etiology. Recent genetic association studies have implicated the apolipoprotein E (APOE) gene in the pathophysiology of primary open angle glaucoma, but there have been conflicting findings. METHODS: To resolve this issue we studied 140 cases and 73 controls that were carefully phenotyped, and used a logistic regression model to simultaneously analyze the effect of apolipoprotein E genotype and functional polymorphisms in the apolipoprotein E gene promoter while controlling for potentially confounding variables. RESULTS: We found no evidence of an association between the apolipoprotein E promoter region polymorphisms and primary open angle glaucoma. CONCLUSIONS: Apolipoprotein E promoter polymorphisms are unlikely to have a major impact on the pathophysiology of primary open angle glaucoma.
Dr. T. Ressiniotis, Department of Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
Classification:
3.4.1 Linkage studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)
