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Abstract #11979 Published in IGR 7-1
Slit-lamp needle revision of failed filtering blebs using high-dose mitomycin C
Shetty RK; Wartluft L; Moster MRJournal of Glaucoma 2005; 14: 52-56
PURPOSE: To investigate the efficacy of bleb needle revision with high-dose mitomycin C in reviving failed filtering blebs after 1 year. PATIENTS AND METHODS: We reviewed the charts of 44 patients with one eye that had undergone bleb needle revision with a mixture of 0.1 mL of mitomycin (0.4 mg/mL) mixed with 0.1 mL of non-preserved 1% lidocaine. At least 12 months of follow-up were required. A successful bleb needle revision was defined as one that did not require a subsequent needling, glaucoma surgery, or medication to reach an intraocular pressure (IOP) greater than 4 mmHg but less than 22 mmHg. A qualified success was defined as a successful bleb needle revision that required subsequent needling or medication. RESULTS: The bleb needle revision with high-dose mitomycin was a success or qualified success after 12 months in 28 patients or 64% (95% confidence interval, 50% to 78%). The baseline IOP in these patients was 26.7 ± 8.2 mmHg (range 15 to 48 mmHg) using an average of 1.5 ± 1.5 glaucoma medications. The IOP after 1 year was 13.6 ± 4.0 (range 6 to 21 mmHg) with an average of 0.5 ± 0.8 medications. Of 44 patients, 17 (39%) were successes and 11 (25%) were qualified successes. CONCLUSION: Bleb needle revision with high-dose MMC was effective in reducing the IOP in 64% of eyes with a failed filtering bleb with minimal long-term complications.
Dr. R.K. Shetty, Mayo Clinic Jacksonville, Jacksonville, Florida 32224, USA. shetty.rajesh@mayo.edu
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
12.8.11 Complications, endophthalmitis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
