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Abstract #12702 Published in IGR 7-3
The effect of episcleral veins cauterization on intraocular pressure and retina in rat
Lu X; Duan J; Zhang FChinese Ophthalmic Research 2005; 23: 386-388
OBJECTIVE: To observe the intraocular pressure (IOP) and fundus changes following the episcleral veins cauterization. METHODS: The right eyes of 50 SD rats underwent cauterization of three episcleral veins under the anesthesia. IOP were measured 3 times a day prior to operation and after operation at a regular time interval for three months. The eyeballs from 10 experimental rats were extracted at 4, 8 and 12 weeks after operation respectively for the histopathologic examination by light microscope. RESULTS: (1) The mean IOP was 13.77 ± 1.44 mmHg before operation and 36.15 ± 7.5564 mmHg at the 1st post-operative day, 24.63 ± 3.1347, 24.10 ± 2.1740 and 22.90 ± 3.1780 mmHg at the 1st, 2nd and 3rd post-operative month, rising by 1.85, 1.81, 1.75 and 1.69 times higher than that before operation respectively. There was a decrease of mean IOP 3 postoperative months later but still was statistically higher than that of control eyes and pre-operation (P < 0.01). No significantly statistical change in mean IOP was seen among the different postoperative month. (2) The thickness from retinal inner limiting membrane to surface of ganglion cell layer was 27.37 ± 10.7341 μm the control eye, and 18.25 ± 7.3177, 16.05 ± 8.6515 and 15.17 ± 10.7498 μm at the 1st, 2nd and 3rd post-operative month, showing that the retinal outer layer of model rats was obviously thinner than that control eyes (P < 0.01) and a insignificantly thinner as the time prolong. In addition, retinal inner layer in model group was insignificantly thinner in comparison with control group (P > 0.05). CONCLUSION: Cauterization of episcleral veins results in a long-term higher IOP, furthermore the procedure induces retinal neurofibril changes in SD rat. LA: Chinese
Dr. X. Lu, Ophthalmology Laboratory, Chengdu Traditional Chinese Medicine University, Chengdu 610075, China
Classification:
5 Experimental glaucoma; animal models
