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Abstract #14219 Published in IGR 8-3

Experimental study of TGF-β₂ antisense oligodeoxynucleotide as a anti-scarring agent in glaucoma surgery

Li J; Fu P; Li X
Chinese Ophthalmic Research 2006; 24: 277-280

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OBJECTIVE: Currently available anti-scarring regimens for glaucoma filtration surgery have potentially blinding complications and thus more attentions should be paid to the need for alternative and safer agents. This experiment was to investigate the effect of TGF-β₂ antisense oligodeoxynucleotide on differentiation and proliferation of subconjunctival fibroblast following glaucoma filtration surgery. METHODS: Glaucoma filtration surgery were performed on both eyes of 28 rabbits. TGF-β₂ antisense oligodeoxynucleotide was subconjunctivally injected in the right eyes (A group), and TGF-β₂ missense oligodeoxynucleotide (B group) or PBS (C group) was used at the same method in the left eyes. Rabbits were killed at 4,7,14 and 28 days after surgery. Intraocular pressure (IOP), bleb characteristics including length, width, and height were recorded at different time point. Subconjunctival fibroblasts were examined by immunohistochemical assay and electron microscopy. RESULTS: The IOP of rabbits was significantly decreased at 14 days (6. 74 ± 1.18 mmHg) and 21 days (8.15 ± 1.97 mmHg) after operation in comparison with B group (8.53 ± 1.04, 9.72 ± 1.09 mmHg) (P < 0.01) and C group (8.79 ± 1.21, 9.43 ± 1.27 mmHg) (P < 0.05). The mean bleb survival time was longer (17.2 days) in A group than B group (14.5 days) and in C group (13.5 days) (P < 0.05). The population of cells expressing α-smooth muscle actin (α-SMA) and proliferating cell nuclear antigen (PCNA) was significantly reduced in A group. The ultrastructure of fibroblast was not altered by TGF-β₂ anti-sense oligodeoxynucleotide. CONCLUSION: TGF-β₂ antisense oligodeoxynucleotide can prevent the scar forming after glaucoma surgery by inhibiting the differentiation and proliferation of subconjunctival fibroblast. It will be a potentially useful development in the prevention of late surgical failure. LA: Chinese

Dr. J. Li, Department of Ophthalmology, People's Hospital, Peking University, Beijing 100044, China

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Classification:

12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)

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