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Abstract #14307 Published in IGR 8-3
The value of the Heidelberg retina tomograph-II in detection of primary chronic angle-closure glaucoma
Li C; Duan X-C; Zhou Y-H; Luo Z-WOphthalmology in China 2006; 15: 114-118
OBJECTIVE: To evaluate the value of the Heidelberg retina tomograph-II in detection of primary chronic angle-closure glaucoma(CACG) in a Chinese population, and to investigate the difference of parameters detected by HRT-II between normal subjects and CACG patients. To evaluate the sensitivity and specificity of optic disk detection using Moorfields regression analysis (MRA) and linear discriminant function (LDF) of the HRT-II in differentiating normal from CACG eyes. DESIGN: Prospective, comparative case series. PARTICIPANTS: 64 eyes of 32 normal subjects and 77 eyes of 51 patients with CACG were studied. The normal subjects were age- and refraction-matched with the glaucoma patients. METHODS: The interventions consisted of optic disk imaged by means of HRT-II and visual field (VF) detected with Oculus Twinfield perimetry. The CACG patients then were divided into two groups according to the VF discriminant standard and mean defect (MD) of Oculus Twinfield perimetry, the group with the glaucomatous VF defect and the group without VF defect. The optic disk was described with 14 optic disk parameters. The optic disc parameters between the normal and the patients were compared. The optic disks were also classified as 'normal/borderline/outside normal limits' on the basis of MRA. The results from MRA and from LDF provided in the HRT-II were compared. Main outcome measures: Optic disk parameters, MD of the VF, the VF discriminant standard, the sensitivity and specificity of HRT-II examination. RESULTS: Between the normal and CACG patients, differences of the most of optic disk parameters were significant statistically (P < 0.05), and the differences of parameters between the three groups were also significant statistically (P < 0.05) except for disk area and height variation contour. The optic disk parameters were compared in two groups at random of three ones. The difference of almost all the optic disk parameters were statistically significant (P < 0.05) between the normal subjects and the patients with VF defect or between the groups with and without VF defect. And only the differences of the rim volume and RNFL cross sectional area were statistically significant(P < 0.05) between the normal subjects and the patients without VF defect. The sensitivity and specificity of the MRA examination in detecting glaucomatous VF defect of CACG were 74.42%, 95.31%, respectively; the sensitivity and specificity of the LDF were 69.77% and 92.19%, respectively. The sensitivity and specificity of the MRA in detecting CACG were 55.84% and 95.31%, that of the LDF were 49.35% and 92.19%, respectively. CONCLUSIONS: HRT-II is a new technique which can examine the optic disc in diagnosis of the CACG. Rim volume and RNFL cross sectional area showed significant differences between the normal subjects and the CACG patients in early stage. HRT-II showed a more accurate diagnosis in CACG with glaucomatous VF changes. In a clinical setting include normal subjects and patients with CACG, the MRA showed a good degree of diagnostic accuracy. LA: Chinese
Dr. X.-C. Duan, Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha Hunan 410011, China
Classification:
6.9.1 Laser scanning (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis)
9.3 Primary angle closure glaucomas (Part of: 9 Clinical forms of glaucomas)
