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Abstract #15240 Published in IGR 8-4
Use of amniotic membrane as an adjuvant in refractory glaucoma
Drolsum L; Willoch C; Nicolaissen BActa Ophthalmologica Scandinavica 2006; 84: 786-789
PURPOSE: To evaluate the results after amnion-shielded trabeculectomy with concomitant use of mitomycin C. METHODS: The study comprised patients with severely refractory glaucomas who had previously undergone two or more regular trabeculectomies with mitomycin C and, in one case, cyclodestructive cryotherapy. The patients were admitted for surgery between May 2003 and May 2004. Trabeculectomy was performed through a limbus-based incision in nine eyes of nine patients. Cryopreserved human amniotic membranes obtained from our biobank were impregnated with 0.4 mg/ml mitomycin C and washed for 2 mins in balanced salt solution. One membrane was sutured to the scleral surface and partly positioned under the scleral flap, and another was secured to subconjunctival tissue. RESULTS: The mean preoperative intraocular pressure (IOP) was 32.2 mmHg (range 22-44 mmHg). After a follow-up of 6-18 months (mean 9.8 months), the mean IOP was 16.4 mmHg (range 11-26 mmHg). The mean number of glaucoma medications was reduced from 2.4 preoperatively to 1.4 postoperatively. There were no devastating complications. CONCLUSIONS: Amnion-shielded trabeculectomy is a procedure that should be evaluated as an option in refractory glaucoma.
Dr. L. Drolsum, Department of Ophthalmology, Centre of Eye Research, Ulleval University Hospital, Oslo, Norway. Liv.Drolsum@uus.no
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
