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Abstract #15669 Published in IGR 2-3
Efficacy and side effects of latanoprost monotherapy compared to adding dorzolamide to timolol in patients with glaucoma and ocular hypertension: a three-month randomised study
Sanchez JGEuropean Journal of Ophthalmology 2000; 10: 198-204
PURPOSE: To compare the efficacy and safety of latanoprost monotherapy or dorzolamide and timolol in glaucoma patients inadequately controlled on adrenergic beta-receptor antagonist therapy. METHODS: A total of 164 patients with primary open-angle glaucoma, capsular glaucoma or ocular hypertension were included in a three-month, open-label, randomized multicenter study. Patients with open-angle glaucoma were required to have an IOP of at least 22 mmHg and patients with ocular hypertension were required to have an IOP of at least 27 mmHg, on treatment with one or two ocular hypotensive drugs, of which at least one had to be a beta blocker. All patients were treated with timolol, 5 mg/ml twice daily, for a two to four week run-in period. They were then randomized to latanoprost, 50 μg/ml once daily, or timolol 5 mg/ml plus dorzolamide, 20 mg/ml twice daily. The difference in mean diurnal IOP change from baseline to month 3 was compared in the two groups. RESULTS: When patients were switched to latanoprost, mean diurnal IOP was reduced by 5.2 mmHg (23%) compared to 4.0 mmHg (17%) in the group in which dorzolamide was added to timolol. The difference of 1.2 mmHg was statistically significant (p = 0.005). The majority of adverse events during both treatments were judged as mild. CONCLUSIONS: The results suggest that a switch to latanoprost monotherapy is an alternative to combined treatment with timolol and dorzolamide in patients inadequately controlled on a topical adrenergic beta-receptor antagonist alone.
Prof. J.G. Sanchez, Hospital Clinico San Carlos, Servicio de Oftalmologia, Facultad de Medicina, C/ Dr. Martin Lagos, s/n, 28040 Madrid, Spain
Classification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
11.4 Prostaglandins (Part of: 11 Medical treatment)
11.5.2 Topical (Part of: 11 Medical treatment > 11.5 Carbonic anhydrase inhibitors)
