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Abstract #15776 Published in IGR 2-3
Intraocular pressure, anterior chamber depth and axial length following intravenous mannitol
Mauger TF; Nye CN; Boyle KAJournal of Ocular Pharmacology and Therapeutics 2000; 16: 591-594
The intraocular pressure (IOP), anterior chamber depth (ACD), and axial length (AL) were measured in 38 eyes of 19 subjects before and after intravenous mannitol injection (12.5 g). Intraocular pressures dropped over the initial 30 minutes then rose back to baseline by two hours. Time 0 minutes: 14.2 mmHg, 15 minutes: 12.7 mmHg, 30 minutes: 11.4 mmHg, 60 minutes: 12.0 mmHg, 90 minutes: 13.2 mmHg, and 120 minutes: 14.1 mmHg. Sitting and supine, ACD and AL did not change following mannitol injection. This study supports an ocular hypotensive effect of mannitol without reducing vitreous volume using a relatively low dose of mannitol (12.5 g). This finding has important implications for its use in ocular surgery at this dosage.
Dr. T.F. Mauger, Department of Ophthalmology, The Ohio State University, Columbus, OH 43210, USA
Classification:
11.6 Osmotic treatment (Part of: 11 Medical treatment)
