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Abstract #15818 Published in IGR 2-3
Two cases of primary open-angle glaucoma with serum autoantibody against retinal ganglion cells
Ikeda Y; Ohguro H; Maruyama IJapanese Journal of Ophthalmology 2000; 44: 648-652
PURPOSE: To present two cases of primary open angle glaucoma (POAG) with serum autoantibody against retinal 25 kDa or 50 kDa antigen. METHODS: Ocular examinations were performed on a 60-year-old man (case 1) and a 74-year-old woman (case 2). The authors also performed serological and immunological examinations, including Western blot analysis and immunocytochemical analysis. RESULTS: In Western blot analysis, the patients were found to have serum autoantibody against retinal 25 kDa or 50 kDa antigen, and immunocytochemical analysis revealed that retinal ganglion cell layers were specifically labelled by each patient's IgG. CONCLUSIONS: The authors report on two interesting cases of POAG with serum autoantibody against retinal 25 kDa or 50 kDa antigen.
Dr. Y. Ikeda, Department of Ophthalmology, Sapporo Medical University School of Medicine, Sapporo, Japan
Classification:
9.2.2 Other risk factors for glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
