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Abstract #15895 Published in IGR 2-3
Bilateral superior cervical ganglionectomy increases choroidal blood flow in the rabbit
Chou P-I; Lu D-W; Chen J-TOphthalmologica 2000; 214: 421-425
In this study, the authors evaluate the effect of bilateral superior cervical ganglionectomy on albino rabbit choroidal blood flow (CBF) during changes of perfusion pressure (PP). Twenty albino rabbits of either sex, weighing between 2.0 and 3.0 kg, were randomly divided into two groups. The experimental group (group S) included ten rabbits (20 eyes) that received bilateral superior cervical ganglionectomy one week prior to the study. The other ten rabbits (20 eyes) served as a control (group N): each received the same procedure as group S except that the superior cervical ganglion was preserved. By means of a laser Doppler flowmeter (Perimed PF4001), blood cell flux (PF), velocity (V), and concentration of moving blood cells (CMBC) were recorded simultaneously while intraocular pressure was increased linearly by a syringe pump. Blood pressure and intraocular pressure were continuously monitored. The laser beam focused on the posterior pole away from major retinal vessels. When PP decreased from 75-0 mmHg in group N, PF, V and CMBC decreased from 100% to 6.94 ± 0.91%, 8.41 ± 0.87%, and 19.38 ± 1.11%, respectively; in group S, this was 17.75 ± 2.58%, 16.78 ± 1.48%, and 34.58 ± 4.42%, respectively. Group S had higher PF, V, and CMBC than group N, while PP decreased gradually. These results indicate that the superior cervical ganglion plays a role in CBF regulation. Bilateral sympathectomy led to a higher PF in group S rabbits, indicating that increased CBF, PF, V, and CMBC remained constant until PP < 55 mmHg demonstrated the existence of CBF autoregulation within a limited perfusion range in both groups. This autoregulation did not change after sympathectomy.
Dr. P.-I. Chou, Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
