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1 General aspects (0)   1.1 Epidemiology (5)   1.2 Population genetics (19)   1.3 Pathogenesis (9)   1.4 Quality of life (2)   1.5 Glaucomas as cause of blindness (0)   1.6 Prevention and screening (5) 2 Anatomical structures in glaucoma (0)   2.1 Conjunctiva (0)   2.2 Cornea (6)   2.3 Sclera (0)   2.4 Anterior chamber angle (0)   2.5 Meshwork (6)     2.5.1 Trabecular meshwork (0)     2.5.2 Schlemms canal (0)     2.5.3 Scleral outlet channels (0)   2.6 Aqueous humor dynamics (2)     2.6.1 Production (0)     2.6.2 Outflow (0)       2.6.2.1 Trabecular meshwork (0)       2.6.2.2 Uveoscleral (0)     2.6.3 Compostion (0)   2.7 Episcleral veins and venous pressure (0)   2.8 Iris (0)   2.9 Ciliary body (0)   2.10 Lens (0)   2.11 Vitreous body (0)   2.12 Choroid, peripapillary choroid, peripapillary atrophy (0)   2.13 Retina and retinal nerve fibre layer (16)   2.14 Optic disc (18)   2.15 Optic nerve (0)   2.16 Chiasma and retrochiasmal central nervous system (0)   2.17 Stem cells (0)   2.20 Other (0) 3 Laboratory methods (0)   3.1 Microscopy (1)   3.2 Electron microscopy (0)   3.3 Immunohistochemistry (2)   3.4 Molecular genetics (1)     3.4.1 Linkage studies (0)     3.4.2 Gene studies (0)   3.5 Molecular biology incl. 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associated with intraocular tumors (1)     9.4.9 Glaucomas associated with elevated episcleral venous pressure (2)       9.4.10 Glaucomas associated with hemorrhage (0)     9.4.11 Glaucomas following intraocular surgery (0)       9.4.11.1 Ciliary block (malignant) glaucoma (0)       9.4.11.2 Glaucomas in aphakia and pseudophakia (1)       9.4.11.3 Epithelial, fibrous, and endothelial proliferation (0)       9.4.11.4 Glaucomas associated with corneal surgery (3)       9.4.11.5 Glaucomas associated with vitreoretinal surgery (0)     9.4.15 Glaucoma in relation to systemic disease (3)     9.4.20 Other (0) 10 Differential diagnosis e.g. anterior and posterior ischemic optic neuropathy (6) 11 Medical treatment (0)   11.1 General management, indication (7)   11.2 Cholinergic drugs (1)   11.3 Adrenergic drugs (0)     11.3.1 Epinephrine (0)     11.3.2 Thymoxamine, dapiprazole (0)     11.3.3 Apraclonidine, brimonidine (12)     11.3.4 Betablocker (16)     11.3.5 Other (0)   11.4 Prostaglandins 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Miscellaneous (7)

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Abstract #15896 Published in IGR 2-3

In vitro diffusion of mitomycin-C into human sclera after episcleral application: impact of diffusion time

Georgopoulos M; Vass C; El Menyawi I; Radda S; Graninger W; Menapace R
Experimental Eye Research 2000; 71: 453-457

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The purpose of this study was to investigate the impact of different diffusion times of mitomycin C (MMC) on the intrascleral concentration versus depth profile of MMC in an experimental model. Scleral quadrants of eight human donor eyes were exposed to sponges soaked with MMC for an application time of one minute. After irrigation with 40 ml saline, the authors allowed further diffusion of MMC in the scleral for one, five, 14, and 29 minutes, until the specimens were further processed. A central 8-mm diameter scleral disc was horizontally dissected with a kryotome at -20°C. MMC concentrations of six layers of 140 μm thickness were analyzed by means of high-performance liquid chromatography. The MMC concentrations (μgg^-1) of layer 1 were: 13.45 ± 5.9 (mean ± SD at two minute diffusion time), 6.7 ± 2.5 (six minute diffusion), 5.6 ± 3.1 (15 minute diffusion), and 3.6 ± 1.7 (30 minute diffusion). The corresponding MMC concentrations of layer 6 were: 0.61 ± 0.48, 1.47 ± 0.66, 1.83 ± 0.42, and 2.98 ± 0.97 μgg^-1. The superficial concentration of intrascleral MMC decreased with increasing diffusion time, the deep concentrations increased. After 30 minutes' diffusion time, equal concentrations of MMC were found in all layers. Even with current low-dose application regimens of MMC, the concentrations in the inner side of the scleral rapidly increase beyond the limits of the therapeutic range. Owing to this fast diffusion of MMC, the only means of reducing ciliary body concentrations of MMC is to reduce the dose.

Dr. M. Georgopoulous, Universitätsklinik für Augenheilkunde und Optometrie, Allgemeines Krankenhaus Wein, Währinger Gürtel 18-20, A-1090 Vienna, Austria. michael.georgopoulos@akh-wien.ac.at

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Classification:

12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)

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