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Abstract #15945 Published in IGR 2-3
Jaborandi: Pilocarpus microphyllus stapf ex wardleworth
Scheerer JZeitschrift für Phytotherapie 2000; 21: 220-230
This article summarizes the current knowledge of Pilocarpus microphyllus Stapf and its active ingredient, pilocarpine. Firstly, the connection between P. microphyllus and the term Jaborandi is explained in a historical context. As well as the origin and use of the term Jaborandi, information is given on the first descriptions of plants under such a term, as well as former applications of the drug known as Jaborandi. Furthermore, efforts regarding the scientific identification of the Jaborandi leaf material imported into Europe are described, followed by a summary of the most important sources of pilocarpine and their synonyms. As well as a botanical description of P. microphyllus and information on its distribution, extraction of the raw material of the plant and the production process for pilocarpine are also described. This part is completed by a brief reference to analytical methods, information on the natural pilocarpine content of the leaves, the synthesis and biosythesis of the substance, as well as the production of pilocarpine by cell cultures. A list of today's known secondary alkaloids, which are found in the leaves of Pilocarpus, is followed by a summary of the degradation problems of pilocarpine. Information on the pharmacology of the alkaloid range from first investigations in 1867, from its meaning to ophthalmology to its applications in xerostomia treatment and cosmetic purposes. Finally, the future significance of pilocarpine is discussed based on changes in glaucoma therapy.LA: German
J. Scheerer, C/. Barcelona, 155, 17001 Girona, Spain
Classification:
11.2 Cholinergic drugs (Part of: 11 Medical treatment)
