advertisement
Abstract #16805 Published in IGR 9-1
The 'two global flash' mfERG in high and normal tension primary open-angle glaucoma
Palmowski-Wolfe AM; Todorova MG; Orguel S; Flammer J; Brigell MDocumenta Ophthalmologica 2007; 114: 9-19
PURPOSE: To analyse the sensitivity of the '2 global flash' multifocal electroretinogram (mfERG) to detect glaucomatous dysfunction in normal tension (NTG) and high tension primary open angle glaucoma (POAG) patients. METHODS: MfERGs were recorded from 20 NTG and 20 POAG patients and compared to those of 20 controls. The mfERG array consisted of 103 hexagons. Each m-sequence step started with a focal flash that could be either dark or light (m-sequence: 2^13, L (max): 200 cd/m2 , Lmin : 1 cd/m2 ), followed by two global flashes (LMAX>/sup> : 200 cd/m2 ) at an interval of approximately 26 ms. Focal scalar products (SP) were calculated using focal templates derived from the control recordings (VERIS 4.8). We analyzed 5 response averages (central 7.5 ° and 4 adjoining quadrants) of the response to the focal flash, the direct component at 10-40 ms (DC) and the following two components induced by the effects of the preceding focal flash on the response to the global flashes at 40-70 ms (IC-1) and at 70-100 ms (IC-2). RESULTS: Both NTG and POAG patients differed from controls in the IC-1 response to the superior quadrants, and POAG patients also differed from controls in the centre. The most sensitive parameter was the IC-1 of the superior temporal quadrant with an area under the ROC curve of 0.82 for POAG and 0.79 for NTG. The DC and the IC-2 did not differ significantly between the groups. When all five response averages of the IC-1 were taken into consideration 90% of the NTG patients and 85% of the POAG patients were correctly classified as abnormal while 80% of the control subjects were correctly classified as normal. CONCLUSIONS: This stimulus sequence holds promise for the diagnosis of early functional changes in POAG. A new finding is that both NTG, as well as POAG can be differentiated from control subjects.
Dr. A.M. Palmowski-Wolfe, Department of Ophthalmology, University Eye Hospital, Mittlere Strasse 91, 4012, Basel, Switzerland, palmowskia@uhbs.ch
Classification:
6.7 Electro-ophthalmodiagnosis (Part of: 6 Clinical examination methods)
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
