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Abstract #17496 Published in IGR 9-2
Effect and safety of bimatoprost lowing intraocular pressure in albino rabbits
Li X; Zhao JChinese Ophthalmic Research 2007; 25: 288-291
OBJECTIVE: Bimatoprost is a new prostaglandins, and its strongly lowing intraocular pressure (IOP) effect on open-angle glaucoma has been proved in clinical researches. The goal of this study was to evaluate the effect, safety of bimatoprost in lowing IOP in albino rabbits. METHODS: Twelve albino rabbits were utilized in this study. 25 μl of bimatoprost drops was topically administrated in one eye of each rabbit and sterile normal saline was used in the same way in the fellow eye. IOP of both eyes was measured before drug administration and 0.5,1,2,5,12,14,20 and 24 hours after use of bimatoprost drops to draw the IOP curve in 4 rabbits, and the dynamic changes of IOP, status of conjunctiva and size of pupil were recorded and assessed in 8 experimental rabbits during continuous administration of bimatoprost for 21 days. RESULTS: IOP decreased by 25% - 32% half an hour after the application of bimatoprost in albino rabbit and the effect lasted over 24 hours. During administration of drug, IOP of experimental rabbits kept a tendency of decrease for 3 weeks and the IOP was (7.35 ± 0.46) mmHg. No significant effect of bimatoprost was found on the pupil size within 24 hours after the application of bimatoprost. Slight conjunctival hyperemia was seen in the early stage in most eyes half an hour after application of bimatoprost but alleviated after 5 hours. One week later, conjunctival hyperemia became steady and slight. CONCLUSION: 0.03% bimatoprost can lower IOP and is safe in normal albino rabbit eyes. LA: Chinese
Dr. X. Li, Department of Ophthalmology, Peking Union Medical College Hospital, Beijing 100730, China. aspirinli@126.com
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
5.3 Other (Part of: 5 Experimental glaucoma; animal models)