advertisement
Abstract #17575 Published in IGR 9-2
No association between variations in the WDR36 gene and primary open-angle glaucoma [9]
Fingert JH; Alward WLM; Kwon YH; Shankar SP; Andorf JL; Mackey DA; Sheffield VC; Stone EMArchives of Ophthalmology 2007; 125: 434-436
Glaucoma is the second-leading cause of permanent blindness in developed nations. Of the many forms of glaucoma, primary open-angle glaucoma (POAG) is the most common. Primary openangle glaucoma is a clinically defined condition that is actually a collection of distinct diseases that are all characterized by a progressive optic nerve degeneration associated with insidious loss of visual field. There is a significant genetic contribution to the pathogenesis of POAG,and several loci associated with POAG have been mapped (GLC1A, chromosome 1q24.3-q25.2; GLC1B, chromosome 2cent-q13; GLC1C, chromosome 3q21-24; GLC1D, chromosome 8q23; GLC1E, chromosome 10p15-p14; and GLC1F, chromosome 7q35-q36). Glaucoma genes have been identified at the GLC1A and GLC1E loci.
Dr. J.H. Fingert, Department of Ophthalmology and Visual Sciences, University of Iowa, College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USA. john-fingert@uiowa.edu
Classification:
3.4.1 Linkage studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)