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Abstract #18273 Published in IGR 3-3
The use of autologous fibrinogen concentrate in treating ocular hypotony after glaucoma filtration surgery
Yieh FS; Lu DW; Wang HL; Chou PIJournal of Ocular Pharmacology and Therapeutics 2001; 17: 443-448
Antimetabolite therapy with 5-fluouracil (5-FU) or mitomycin C (MMC) has significantly improved the success rate of glaucoma filtration surgery. However, in some eyes, when filtration is excessive, persistent hypotony may develop. In this study, the authors describe the experience of using autologous fibrinogen concentrate (AFC) to treat patients with persistent hypotony after glaucoma filtration surgery. Among seven MMC-augmented trabeculectomy patients who developed persistent postoperative hypotony, the effects of AFC intrableb injections were evaluated. Under a microscope, 0.2 ml AFC and bovine thrombin were injected into the blebs of the patients from both sides of the filtering blebs. Postoperative best-corrected visual acuity, anterior chamber status, intraocular pressure (IOP) and fundus examination were followed and compared with those preoperative. On the second day, the mean IOP of seven eyes elevated from preoperative 3.4 ± 2.1 mmHg to 12.6 ± 4.2 mmHg, and the anterior chamber became deep without obvious inflammatory response. Within two weeks, macular edema and visual acuity were noted to improve in six eyes (85.7%). In addition, after a mean follow-up of 25 months, the trabeculectomy procedure remained successful in all eyes. AFC appears to be safe and effective in the treatment of ocular hypotony after glaucoma filtration surgery.
Dr D.-W. Lu, Department of Ophthalmology, Tri-Service General Hospital, Cheng-Kong Road, Taipei 114, Taiwan p310849@ms23.hinet.net
Classification:
12.8.11 Complications, endophthalmitis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)