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Abstract #19111 Published in IGR 3-1
Effect on intraocular pressure during 24 hours after repeated administration of the fixed combination of latanoprost 0.0005% and timolol 0.5% in patients with ocular hypertension
Larsson LIJournal of Glaucoma 2001; 10: 109-114
PURPOSE: To measure the effect on intraocular pressure (IOP) for 24 hours after repeated administration of the fixed combination of latanoprost 0.005% and timolol 0.5%. METHODS: A randomized, double-masked, placebo-controlled, crossover study including 20 patients with ocular hypertension was carried out. Patients were randomized to treatment with the fixed combination of latanoprost and timolol or with placebo. The eye drop was taken at 8 a.m. After two weeks of treatment, the patients were hospitalized, and the IOP was measured at 8 a.m., and thereafter every other hour until midnight, and also at 3, 6, and 8 a.m. After a washout period of four weeks, the patients switched to the other eye drop, and after two weeks of treatment, were hospitalized and the IOP measurements were repeated at the same intervals. RESULTS: The mean 24-hour IOP was 14.7 ± 0.3 mmHg (mean ± standard error of the mean) for latanoprost and timolol, and 19.4 ± 0.3 mmHg for placebo. This corresponds to a significant difference in IOP of 4.7 ± 0.4 mmHg (95% confidence interval 3.8-5.8; p < 0.001) between the two treatments in favor of the combination. At all measured time points, except 3 a.m., the mean IOP was lower with latanoprost and timolol than with placebo. During the daytime measurements, the mean IOP was 13.9 ± 0.7 mmHg for the fixed combination and 19.5 ± 0.7 mmHg for the placebo. Corresponding figures at nighttime were 16.1 ± 0.7 and 19.2 ± 0.7 mmHg, respectively. CONCLUSIONS: The fixed combination of latanoprost and timolol significantly reduced IOP after administration one daily for two weeks in patients with ocular hypertension. A reduction in IOP during a 24-hour period was seen, with a greater IOP reduction during the daytime compared with nighttime. The fixed combination applied once daily could be a convenient alternative to concomitant therapy with its individual components.
Dr L.-I. Larsson, Department of Ophthalmology, Uppsala University Hospital, S-751 85 Uppsala, Sweden
Classification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
