advertisement
Abstract #19257 Published in IGR 9-3
A novel single nucleotide polymorphism, IVS2 -97A>T, in the prostaglandin F2α receptor gene was identified among the Malaysian patients with glaucoma
Hoh BP; Zahary MN; Tajudin LSA; Chieng LL; Cheong MT; Sidek MR; Zulkifli A; Zilfalil BAKobe Journal of Medical Sciences 2007; 53: 49-52
The Prostaglandin F2α (PGF2α) receptor gene has been found to play an important role in reducing the intraocular pressure of the glaucomatous patients. Variations of the PGF2α receptor gene may be responsible for the differences in the response to an antiglaucoma drug, Latanoprost. A combined method of denaturing High Performance Liquid Chromatography (dHPLC) and sequencing was applied to detection of the PGF2α receptor gene variant among the 76 Malaysian patients with glaucoma, and a novel single nucleotide polymorphism (SNP), IVS -97A>T, was identified. According to the genotyping analysis, 36.8% of the subjects were heterozygous for the variant allele T, while 9.2% homozygous. The frequency of variant allele T was 0.28. Although with a limited number of samples, our data suggested that this polymorphism is common in the Malaysian patients with glaucoma.
Dr. B.P. Hoh, Human Genome Centre, School of Medical Science, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia
Classification:
3.4.2 Gene studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)