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Abstract #19415 Published in IGR 9-3
Ibopamine stimulates α-Adrenergic receptors and D1 dopaminergic receptors in the eye
Giuffre ICurrent Drug Therapy 2007; 2: 127-132
Ibopamine stimulates α-adrenergic receptors and D1-dopaminergic receptors in the eye. Ibopamine is a dopamine analogue and it is hydrolysed to epinine by the esterases in the aqueous humor. Adrenergic stimulation determines the non-cycloplegic mydriatic effect, while the D1-dopaminergic activity is responsible for an increase in aqueous humor production. Ibopamine is effective as a mydriatic before and after surgical procedures. Its main uses are: provocative test in glaucoma; treatment of ocular hypotony; evaluation of the outflow pathways of the aqueous humor. Ibopamine test is positive in 92% of patients affected by primary open-angle glaucoma (POAG), while it is negative in healthy eyes. It is useful in relatives of glaucomatous patients.
Dr. I. Giuffre, Department of Ophthalmology, Medical School, University of Roma Tor Vergata, Via Seneca, 34, 00136 Roma, Italy. italogiuffre@libero.it
Classification:
6.13 Provocative tests (Part of: 6 Clinical examination methods)
