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1 General aspects (0)   1.1 Epidemiology (11)   1.2 Population genetics (2)   1.3 Pathogenesis (4)   1.4 Quality of life (8)   1.5 Glaucomas as cause of blindness (7)   1.6 Prevention and screening (4) 2 Anatomical structures in glaucoma (0)   2.1 Conjunctiva (0)   2.2 Cornea (23)   2.3 Sclera (3)   2.4 Anterior chamber angle (5)   2.5 Meshwork (0)     2.5.1 Trabecular meshwork (10)     2.5.2 Schlemms canal (0)     2.5.3 Scleral outlet channels (0)   2.6 Aqueous humor dynamics (0)     2.6.1 Production (0)     2.6.2 Outflow (1)       2.6.2.1 Trabecular meshwork (1)       2.6.2.2 Uveoscleral (0)     2.6.3 Compostion (3)   2.7 Episcleral veins and venous pressure (0)   2.8 Iris (2)   2.9 Ciliary body (1)   2.10 Lens (0)   2.11 Vitreous body (0)   2.12 Choroid, peripapillary choroid, peripapillary atrophy (2)   2.13 Retina and retinal nerve fibre layer (21)   2.14 Optic disc (14)   2.15 Optic nerve (2)   2.16 Chiasma and retrochiasmal central nervous system (1)   2.17 Stem cells (1)   2.20 Other (0) 3 Laboratory methods (0)   3.1 Microscopy (6)   3.2 Electron microscopy (0)   3.3 Immunohistochemistry (6)   3.4 Molecular genetics (0)     3.4.1 Linkage studies (0)     3.4.2 Gene studies (12)   3.5 Molecular biology incl. 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Miscellaneous (9)

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Abstract #19832 Published in IGR 9-4

Change of rabbits' eyeballs with chronic intraocular hypertension

Yang X-G; Yu J-N; Wang X-J
International Journal of Ophthalmology 2007; 7: 948-950

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AIM: To investigate the changes of rabbits' eyes with chronic increase of intraocular pressure (IOP). METHODS: IOP was increased chronically in five rabbits by an injection of 0.2 ml compound carbomer solution into anterior chamber, and the other five rabbits served as control. The intraocular pressure (IOP) was measured every day. After four weeks, eyeground photographs were taken. All optic nerves and retinas of rabbits were examined by a conventional microscope. RESULTS: The anterior segment of the eye, optic disk and cribrum appearance of the eyeball looked normal in control eyes in all specimens. While in experimental eyes, the optic disk was deepened, and the cribrum was deformed. CONCLUSION: Chronic intraocular hypertension significantly affects the eyeball. This change might be responsible for the irreversible damage of visual activity induced by chronic intraocular hypertension, similar to clinic manifestation of chronic glaucoma. LA: Chinese

Dr. X.-G. Yang, Department of Ophthalmology, Fourth Hospital, Xi'an 710004 Shaanxi Province, China. yangxinguang@hotmail.com

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Classification:

5.3 Other (Part of: 5 Experimental glaucoma; animal models)
3.1 Microscopy (Part of: 3 Laboratory methods)

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