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Abstract #20460 Published in IGR 10-1
Aqueous humor protein concetration in patients with primary open-angle glaucoma under clinical treatment
dos Santos Prata T; Navajas EV; Melo Jr LAS; Martins JRM; Nader HB; Belfort Jr RArquivos Brasileiros de Oftalmologia 2007; 70: 217-220
PURPOSE: To compare total protein concentration in the aqueous humor of primary open-angle glaucoma and non-glaucomatous patients. METHODS: Aqueous humor samples were obtained from 22 patients just before trabeculectomy for clinically uncontrolled primary open angle glaucoma (POAG group). Aqueous humor (0.1 mL) was aspirated by inserting a 26-gauge needle into the anterior chamber. The same procedure was performed in 22 non-glaucomatous patients just before cataract surgery (control group). Immediately after collection, the aqueous humor was stored at -20°C. Aqueous humor total protein concentration was determined using a colorimetric assay. RESULTS: The geometric mean of total protein concentration of the aqueous humor samples was 32 mg/dL (range: 8-137 mg/dL) in the primary open angle glaucoma group and 16 mg/dL (range: 2-85 mg/dL) in the control group. The ratio of the protein concentration between the two groups was 2.0 (95% confidence interval: 1.3 to 3.2; p=0.003). CONCLUSIONS: The total protein concentration in primary open-angle glaucoma aqueous humor was approximately two times higher than that in non-glaucomatous subjects. LA: Portuguese
Dr. T. Dos Santos Prata, Al. Campinas 1232, Sao Paulo, SP 01404-001, Brazil. tiagoprata@oftalmo.epm.br
Classification:
2.6.3 Compostion (Part of: 2 Anatomical structures in glaucoma > 2.6 Aqueous humor dynamics)
