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Abstract #20718 Published in IGR 10-1
A comparative study between biotic amniotic membrane and mitomycin C applied in refractory glaucoma trabeculectomy
Ha S-P; Fan W-Y; Yang Q-LInternational Journal of Ophthalmology 2008; 8: 158-160
AIM: To explore the clinical effects of trabeculectomy with biotic amniotic membrane (amniotic membrane transplantation, AMT) or mitomycin C (MMC) in the treatment of refractory glaucoma. METHODS: In a randomized control clinical trial, 57 eyes of 40 patients with refractory glaucoma underwent trabeculectomy with AMT(32 eyes) or MMC(25 eyes). The former were performed trabeculectomy with AMT under the scleral flap; the latter were intraoperatively administered with MMC, 0.2-0. 4mg/mL via a sponge for 2-4 minutes. The follow-up was 1 year, and the effects of two kinds of surgery were compared. RESULTS: The postoperative conditions were compared with those before the surgery. The intraocular pressure (IOP) of both groups significantly declined (P < 0.01). The decrease of visual acuity occurred in 45% of MMC group, whereas only 10% in AMT group during postoperative 1 to 2 weeks. There was significant difference between two groups (P < 0.05). The postoperative complications induced by AMT were mild, mainly involving the shallow anterior chamber, while the complications of MMC group include thin wall filtering bleb, bleb leaking, choroidal detachment due to ocular hypotension, and so on. CONCLUSION: Application of AMT in trabeculectomy can prevent the filtering bleb from scar formation and the complication was less than that of MMC. It is a safe and effective method for treatment of refractory glaucoma. LA: Chinese
Dr. S.-P. Ha, Department of Ophthalmology, People' Hospital of Ningxia Hui Autonomous Region, Yinchuan 750021, China. hashaoping@163.com
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
