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Abstract #20841 Published in IGR 10-1
Prophylactic use of timolol maleate to prevent intraocular pressure elevation after Nd-YAG laser posterior capsulotomy
Cai JP; Cheng JW; Wei RL; Ma XY; Jiang F; Zhu H; Li YInternational Ophthalmology 2008; 28: 19-22
PURPOSE: To evaluate the effective prophylaxis of topical 0.5% timolol maleate for the intraocular pressure rise following Nd-YAG laser posterior capsulotomy. METHODS: A total of 190 eyes of 184 patients who underwent Nd-YAG laser posterior capsulotomy were randomly assigned to pre-treatment with either topical application of 0.5% timolol maleate (treatment group) or nothing (control group). RESULTS: The mean intraocular pressure (IOP) of the treatment group was 14.8 ± 3.0 mmHg before capsulotomy and 15.7 ± 3.4 mmHg after capsulotomy (P > 0.05), whereas IOP was 15.1 ± 3.3 mmHg and 17. 2 ± 4.3 mmHg (P < 0.05) for the control group. There was no statistically significant difference between the two groups with regard to mean IOP before capsulotomy (P > 0.05), but a statistically significant difference was seen between the two groups after capsulotomy (P < 0.05). Six of 91 eyes (6.6%, two with aphakia) in the treatment group had an IOP elevation greater than 6 mmHg compared with 14 of 99 eyes (14.1%, eight with aphakia) in the control group (P < 0.01). CONCLUSION: Pre-treatment with a topical application of 0.5% timolol maleate is effective in preventing IOP elevation after Nd-YAG laser posterior capsulotomy.
Dr. J.P. Cai, Department of Ophthalmology, Second Affiliated Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, China, netpard@163.com
Classification:
12.15 Capsulotomy (Part of: 12 Surgical treatment)
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)