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Miscellaneous (6)

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Abstract #21155 Published in IGR 10-2

Effects of switching from topical β-blockers to latanoprost on intraocular pressure in patients with normal-tension glaucoma

Ikeda Y; Mori K; Ishibashi T; Naruse S; Nakajima N; Kinoshita S
Journal of Ocular Pharmacology and Therapeutics 2008; 24: 230-234

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AIMS: The effects of switching from topical β-blockers (β) to latanoprost (LA) on intraocular pressure (IOP) and IOP-reduction rate (IOP-RR) in patients with normal-tension glaucoma (NTG) were investigated. Subjects and METHODS: Sixty (60) NTG patients (60 eyes) were divided into three equal groups receiving carteolol hydrochloride (group A), nipradilol (group B), and betaxolol hydrochloride (group C) twice-daily for 3 months. The drugs were changed to topical LA administered once-daily for the next 3 months. RESULTS: Baseline IOP was 14.4 ± 0.9, 14.6 ± 0.6, and 14.6 ± 0.9 mmHg in groups A, B, and C, respectively. At 3 months, IOP was 12.4 ± 0.6, 13.4 ± 0.6, and 12.9 ± 0.8 mmHg and 10.5 ± 0.5, 11.1 ± 0.8, and 11.7 ± 0.8 mmHg at 6 months in groups A, B, and C, respectively. At 3 months, IOP-RR was 10.4 ± 5.5, 9.5 ± 2.6, and 10.8 ± 4.7% and 24.1 ± 4.3, 22.9 ± 5.9, and 19.4 ± 3.8% at 6 months in groups A, B, and C, respectively. The groups did not significantly differ in the first 3 months regarding IOP and IOP-RR. Switching to LA significantly decreased IOP and increased IOP-RR in all groups. CONCLUSION: In NTG patients, LA reduced IOP more effectively than the β tested.

Dr. Y. Ikeda, Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku Kyoto 602-0842, Japan. yikeda@ophth.kpu-m.ac.jp

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Classification:

9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
11.4 Prostaglandins (Part of: 11 Medical treatment)
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)

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