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Abstract #21234 Published in IGR 10-2
Evaluation of the visual system in a rat model of chronic glaucoma using manganese-enhanced magnetic resonance imaging
Chan KC; Fu QL; So KF; Wu EXConference proceedings : Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2007; 2007: 67-70
This study aims to employ in vivo manganese-enchanced MRI (MEMRI) to evaluate dynamically the Mn2+ enhancements along the visual pathway following an induction of ocular hypertension in a rat model of chronic glaucoma. Results showed an accumulation of Mn2+ ions in the vitreous humor of the glaucomatous eye, with no statistical changes in the total retinal thickness but a possible occlusion of the ions at the optic nerve head. Meanwhile, there was a reduction in Mn2+ transport in the glaucomatous optic nerve in the later stage of our model. Fewer enhancements in the visual cortex projected from the glaucomatous eye were also detectable. These may help understand the disease mechanisms, monitor the effect of drug interventions to glaucoma models, and complement the conventional techniques in examining the visual components.
Dr. K.C. Chan, Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong
Classification:
6.30 Other (Part of: 6 Clinical examination methods)
5.1 Rodent (Part of: 5 Experimental glaucoma; animal models)
