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Abstract #21367 Published in IGR 10-2
Effects of change in intraocular pressure on axial eye length and lens position
Leydolt C; Findl O; Drexler WEye 2008; 22: 657-661
PURPOSE: To quantify the biometric changes of ocular dimensions with mechanical elevation of intraocular pressure (IOP) in vivo, to get a better understanding of the elastic properties of the human ocular structures that may play a role in the pathogenesis of various diseases such as myopia or glaucoma. METHODS: Changes in IOP were induced by a suction cup in 18 eyes under cycloplegia. Axial eye length (AEL) and anterior chamber depth (ACD) were measured with non-invasive laser interferometry during elevation of the IOP 10 and 20 mmHg over baseline values and after a 10-min resting period. RESULTS: IOP elevation of 10 and 20 mmHg respectively caused a significant increase of AEL of 23 μm (95% confidence interval: 14-34 μm) and 39 μm (confidence interval (CI): 28-51 μm). After mechanical oculopression, which resulted in an IOP reduction of -5.1 mmHg (CI: -6.3 to -4.0 mmHg) vsbaseline, a significant shortening of -7 μm (CI: -13 to 0 μm) was observed. The change in AEL correlated with the change in IOP (r = 0.66, P = 0.005). Furthermore, a significant increase in ACD of 30 μm (CI: 24-36 μm) was detected with IOP reduction after oculopression, but no change was seen during IOP elevation. CONCLUSIONS: Biometric changes of the human eye as a response to IOP changes were assessed in vivo. The correlation between change in AEL and IOP found emphasizes the need of in vivo ocular rigidity measurements in the human eye.
Dr. C. Leydolt, Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
Classification:
6.12 Ultrasonography and ultrasound biomicroscopy (Part of: 6 Clinical examination methods)
2.10 Lens (Part of: 2 Anatomical structures in glaucoma)
