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Abstract #21920 Published in IGR 10-4
Melatonin makes me feel awake! Seven years of lab experience (2000-2007)
Pelaez T; Mediero A; Alarma-Estrany P; Loma P; Guzman-Aranguez AI; Crooke A; Kolligris B; Peral A; Pintor JAnales de la Real Academia Nacional de Farmacia 2007; 73: 947-962
The research on the effect of melatonin on intraocular pressure (IOP) is reviewed from the hystorical point of view of our laboratory. The original idea of melatonin modulating intraocular pressure has been improved by using selective compounds for MT(2) and specially melatonin MT(3) receptors. The selective compound 5-methoxyamino N-acetyltryptamine (5-MCA-NAT) has been an attractive compound due to its ability to reduce IOP about 40%, therefore being a good candidate to the treatment of the ocular hypertension linked to glaucoma. More compounds have been developed and tested permitting us to have a more accurate panorama of those receptors controlling the relevant process of intraocular pressure.
Dr. J. Pintor, Dep. Bioquimica, E.U. Optica, Universidad Complutense de Madrid, C/ Arcos de Jalon, s/n, 28037, Madrid, Spain. jpintor@vet.ucm.es