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Abstract #22020 Published in IGR 10-4
Study of ocular pharmacokinetics of in situ gel system for S(-)-satropane evaluated by microdialysis
Fu J; Feng X; Yuan H; Yan L; Kuang X; Xia Z; Gao X; Yu C; Lu Y; Chen H-ZJournal of Pharmacological and Biomedical Analysis 2008; 48: 840-843
S(-)-Satropane is currently being developed to in situ forming ophthalmic gel, a new ophthalmic delivery system, for the treatment of glaucoma. To evaluate the pharmacokinetic profiles of S(-)-satropane, the microdialysis method was employed. The concentration of S(-)-satropane in dialysates was measured by using liquid chromatography/tandem mass spectrometry (LC-MS/MS). Unlike the common solution prepared in normal saline, in which the level of S(-)-satropane in aqueous humor increased rapidly after instillation and reached the maximal level (C(max) of 1.508 ± 0.297 μg ml(-1)) within 1 h, S(-)-satropane exhibited 3.2-fold greater C(max) and 2.2-fold greater AUC(0-3h) (p < 0.05) in the in situ forming gel. The results showed that the in situ forming gel system could improve the ocular bioavailability of S(-)-satropane.
Dr. H.-Z. Chen, Department of Pharmacology, College of Basic Medical Sciences, Shanghai JiaoTong University School of Medicine, South Chongqing Road 280, Shanghai, 200025, China. yaoli@shsmu.edu.cn
