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Abstract #22165 Published in IGR 10-4
Genetic heritability of a shallow anterior chamber in Chinese families with primary angle-closure glaucoma
Tu YS; Yin ZQ; Pen HM; Yuan CMOphthalmic Genetics 2008; 29: 171-176
PURPOSE: To explore the genetic heritability of a shallow anterior chamber (AC) in families with primary angle-closure glaucoma (PACG) and to provide a theoretical basis for the identification of candidate genes responsible for PACG. METHODS: Genetic analyses included familial and segregation analysis, tests for multifactorial inheritance and thresholds. The data was used to determine heritability. The relative risk rate and the possible genetic pattern of a shallow AC were examined in 114 pedigrees with PACG probands. RESULTS: The estimated heritability value of a familial shallow AC was 92.6% ± 5.9%; the relative risk rate of a shallow AC was 7.91. The rate of affected female siblings to affected males was 2.87:1, which was statistically higher than that of affected male siblings (Χ2 = 9.75, P < 0.01). In two different mating types, the segregation ratios of U x U (parents unaffected) and U x A (one parent affected) were 0.11 and 0.426 respectively. The result of segregation analyses suggested that the genetic pattern of Ux U did not possess the characteristics of a monogenetic model and the genetic pattern of U x A exhibited autosomal dominant inheritance traits. CONCLUSIONS: We have shown that there is a higher heritability and a higher relative risk rate in the Chinese population of familial shallow ACs. The inheritance of a shallow AC may be a genetically heterogeneous trait and influenced by gender with autosomal dominant inheritance in subgroups. These results provide a theoretical basis for the identification of candidate genes responsible for Chinese PACG.
Dr. Y.S. Tu, Southwest Eye Hospital/Southwest Hospital, Third Military Medical University, Chongqing, China
