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Abstract #22472 Published in IGR 10-4
Central corneal thickness and glaucoma in adult chinese: The Beijing Eye Study
Xu L; Zhang H; Wang YX; Jonas JBJournal of Glaucoma 2008; 17: 647-653
PURPOSE: The aim of this study was to evaluate whether glaucoma was related to central corneal thickness (CCT). METHODS: The Beijing Eye Study 2006 is a population-based study that included 3251 (73.3%) subjects (aged 45+y) out of the 4439 subjects who had participated in the survey in 2001, and who returned for a reexamination. The main outcome measures were central corneal thickness and presence and progression of glaucomatous optic neuropathy. RESULTS: Measurements of CCT were available for 3100 (95.4%) subjects. CCTs did not vary significantly (P > 0.10) between the 'optic disk glaucoma' [n = 78 (2.5%) subjects; 551 ± 32 μm], the 'perimetric glaucoma' [n = 38 (1.1%) subjects; 550 ± 31 μm], and the normal groups (n = 3022; 556 ± 33 μm). The CCT was not significantly associated with the neuroretinal rim area (P = 0.28) or the mean visual-field defect (measured by frequency-doubling perimetry) (P = 0.22). In multiple regression analysis, the CCT was significantly associated with male sex, (P < 0.001), urban region (P < 0.001), and intraocular-pressure measurements (P < 0.001); whereas it was not significantly (P = 0.17) associated with chronic open-angle glaucoma. During follow-ups from 2001 to 2006, 42 subjects, who showed a progression of, or development of glaucomatous abnormalities of the optic nerve head, did not differ significantly (P = 0.30) in CCTs from the stable group. CONCLUSIONS: CCTs might not be markedly different between glaucomatous and normal eyes. The reasons for the discrepancies between the present population-based study and previous hospital-based investigations might be due to the differences in study design and mode of selection of study participants.
Dr. L. Xu, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China