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Abstract #23010 Published in IGR 11-1
Experimental study on the application of human umbilical vein in non-penitrating trabecular surgery
Pan L; Gao D-W; Shi L; Nie Q-Z; Song G-HInternational Journal of Ophthalmology 2008; 8: 2206-2209
AIM: To experimentally evaluate the effects of human umbilical vein tube implant in non-penitrating trabecular surgery (NPTS) and its toxic and side effects. METHODS: Thirty rabbits underwent bilateral non-penitrating trabecular surgery. An umbilical vein tube was sutured in the scleral bed in one eye, while the other eye served as the control. Intraocular pressure (IOP), filtering bleb, intraocular reactions, histological exams and ultrasound biomicroscopy (UBM) exams of the surgical area were performed postoperatively. RESULTS: Three days after surgery, the bleb formation was similar in two groups. From the 1st to the 5th postoperative week, the number of existing functional bleb in the experimental group was significantly higher than that in the control group (P < 0.05), and there was no statistical difference between the two groups after 6 weeks. Eyes in the experimental group showed longer postoperative IOP-reduction periods than those in the control group (8 weeks vs 2 weeks). From the 1st to the 8th week after surgery, the decreasing of intraocular pressure in the experimental group was significantly greater than that in the control group (P < 0.05). Histological observation showed that in the control group fibroblastic proceeded to completely fill with fibrin clots and fibroblasts by postoperative day 7. In the experimental group, the decompression space was detectable at all histology study periods. The implant can still be seen at the operative site up to week 28 postoperatively. In the postoperative 1-28 weeks, UBM exam showed that the implant was not degraded and the decompression space and still been seen. Mild hyphema occurred in 2 eyes and intraocular hypertension occurred in 1 eye postoperatively. No signs of significant inflammations were observed in other individuals of the two groups during the 28 weeks study, and no signs of foreign-body reaction were detected in all the eyes with umbilical vein implant. CONCLUSION: The use of human umbilical vein in non-penitrating trabecular surgery can prevent the adhesion of filtering channel and it's well biocompatible with no toxity, and this study can provide experimental reference for the clinical use of biomembrane. LA: Chinese
Dr. D.-W. Gao, Department of Ophthalmology, Shengjing Hospital, China Medical University, Shenyang 110004 Liaoning Province, China. gaodw@cmu2h.com
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)