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Abstract #23034 Published in IGR 11-1
Study of the retinal nerve fiber layer thickness measurement using optical coherence tomography in myopic subjects
Cao D; He X-G; Liu T; Sun QInternational Journal of Ophthalmology 2008; 8: 2044-2048
AIM: To evaluate the characteristics of peripapillary retinal nerve fibre layer (RNFL) thickness parameters and to investigate the relationship between RNFL thickness and the diopter in myopic Chinese subjects. METHODS: The peripapillary RNFL of 205 myopic eyes and 68 normal control eyes with aged from 5 to 40 years were imaged on the Stratus OCTTM 3000. Thickness of the RNFL around the disc was determined with 3. 4mm diameter circle OCT scan, and it was measured and analyzed using the RNFL thickness average analysis program. The data were analyzed using SPSS13.0 commercial statistical software. RESULTS: (1) The thickest of RNFL was in 7 : 00 and 11: 00, and the thinnest in 3 according clock type. The thickness of RNFL was thicker in the inferior quadrant (1) and the superior quadrant (S), followed by the temporal quadrant (T), and progressively less in nasal quadrant (N). (2) All of the subjects whose age ranged from 5 to 40 years were divided into four groups: the normal subjects group (68 eyes), the mild myopia group (-0.75D - -3.00D, 68 eyes), the moderate myopia group (-3. 00D - -6. 00D, 68 eyes), the severe myopia group (≥ -6. 00D, 69 eyes). The normal subjects group was as control group, and other three myopic groups compared with it. Some RNFLT parameters including 7: 00, 11: 00, Smax, Imax, Smax/Imax, and Max-Min had no statistically significant differences (P > 0. 05). Some RNFLT parameters including 3: 00, 4: 00, and N had statistically significant differences (P < 0.05). (3) The results by partial correlation analysis of the relationship between the myopic diopter and the RNFLT parameters in the myopic eyes after the age factor was controlled, showed that some RNFLT parameters in the superior and nasal had negative correlation with diopter (r = -0.183 - -0362, P = 0.009 - 0.000, P < 0.05), but 3 : 00, 7 : 00, and 11 : 00, Smax, Imax, Smax/Imax, and Max-Min did not have statistically significant correlation with diopter ( r = 0.0005 - 0. 122, P = 0.942 - 0.082, P>0.05). CONCLUSION: The reducing nasal RNFL thickness measured by OCT is detected in mild myopic Chinese subjects. And it is more obviously in the moderate and severe myopia of them. However, the reducing RFNL thickness is not significant in the temporal part and the temple-inferior part. The characteristics of the myopic RFNL thickness must be considered carefully, when we identify the reducing RFNL thickness between subjects in myopia and patients in primary open angle glaucoma. LA: Chinese
Dr. X.-G. He, Department of Ophthalmology, Daping Hospital, The Third Military Medical University, Chongqing 400042, China. Xiangge_He@hotmail.com
Classification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
8.1 Myopia (Part of: 8 Refractive errors in relation to glaucoma)
