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Abstract #23714 Published in IGR 11-2
The genetics of primary open-angle glaucoma: a review
Allingham RR; Liu Y; Rhee DJExperimental Eye Research 2009; 88: 837-844
Glaucoma is the major cause of irreversible blindness worldwide. Primary open-angle glaucoma (POAG), as the most prevalent form of glaucoma, is a complex inherited disorder and affects more than 2 million individuals in the United States. It has become increasingly clear that a host of genetic as well as environmental factors are likely to contribute to the phenotype. A number of chromosomal and genetic associations have been reported for POAG. This review examines what is currently known about the underlying genetic structure, what remains to be learned, and how this may affect our medical management of this major blinding disease.
Duke University Eye Center, Duke University, Durham, NC 27710, USA. allin002@mc.duke.edu
Classification:
1.2 Population genetics (Part of: 1 General aspects)