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Abstract #24269 Published in IGR 11-3
Hypothesis: Poly-(R)-3-hydroxybutyrate is a major factor in intraocular pressure
Norris V; Bresson-Dumont H; Gardea E; Reusch RN; Gruber DMedical Hypotheses 2009; 73: 398-401
Short chain poly-(R)-3-hydroxybutyrate (cPHB) is a ubiquitous molecule that readily adheres to others, that is covalently added to proteins and that forms, with polyphosphate, ion channels. High levels of cPHB have been implicated in atherosclerosis and in diabetes. Here, we propose a hypothesis in which cPHB adheres to filaments in the extracellular matrix and this raises intraocular pressure. In a corollary, we propose that a positive feedback relationship between cPHB adherence to filaments, raised IOP and filament stretching constitutes a switch.
Dr. V. Norris, Department of Biology, University of Rouen, Mont Saint Aignan, 76821, France. victor.norris@univ-rouen.fr
Classification:
6.1.3 Factors affecting IOP (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
