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Abstract #24372 Published in IGR 11-3
Toxic effects of antiglaucoma drugs on superficial tissues of the eye
Pozarowska DInternational Review of Allergology and Clinical Immunology 2008; 14: 112-114
Glaucoma is a chronic disease which, if untreated, can lead to blindness. Although its pathogenesis still remains unclear the only management of glaucoma consists in lowering of the elevated intraocular pressure, the main risk factor of the disease has a rational basis. In this paper a current opinion on the toxic effects of the application of ophthalmic drops on the surface components of the eye (conjunctiva, cornea, and the corneal stroma) is presented. Apart from the active components conservatives present in the eyedrops are of prime importance in the induction of cytotoxicity. Effects of BAK and the newly developed conservatives, such as SotZia or SOC, on the cornea are discussed. Although the topical application of antiglaucoma drugs can have severe side effects its usefulness in the treatment of glaucoma is undisputed. A once-a-day application of the preservative-free, BAK-free, long-acting eyedrops should be recommended in almost all of the glaucoma cases.
Dr. D. Pozarowska, Department of Ophthalmology, Medical University of Lublin, 1 Chmielna Str., 20-079 Lublin, Poland. dpozarowska@wp.pl
Classification:
11.1 General management, indication (Part of: 11 Medical treatment)
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)
2.1 Conjunctiva (Part of: 2 Anatomical structures in glaucoma)