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Abstract #24442 Published in IGR 11-3
Progress in gene therapy for eye diseases using adeno-associated virus as a vector
Ding Z-X; Tan QInternational Journal of Ophthalmology 2009; 9: 1125-1127
Adeno-associated virus (AAV) is a member of the parvoviridae, and eleven serotypes have been discovered. AAV as gene transfer vector has became a hot spot in gene therapy for eye diseases because of its safety, broad host range, low immunogenicity and long-term expression of therapeutic gene. The following factors may influence on gene transfer in eye: AAV vector serotypes, the pathways of gene transfer and tissue-specific promoters etc. we reviewed the new progression in gene therapy using AAV as a vector for retinal diseases, glaucoma and corneal diseases. LA: Chinese
Dr. Q. Tan, Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha 410008, China. tanqian99@yahoo.com.cn
Classification:
11.9 Gene therapy (Part of: 11 Medical treatment)