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Abstract #24658 Published in IGR 11-4
Conjunctival hyperaemia associated with the fixed combinations of latanoprost/timolol and bimatoprost/ timolol in the treatment of ocular hypertension or glaucoma
Vinuesa MJ; Vinuesa I; Diaz S; Martin I; Soto J; Fernandez-Arias IValue in Health 2009; 12: A453
OBJECTIVES: To assess the association of conjunctival hyperaemia with the fixed combinations of latanoprost/timolol (LT/TM) and bimatoprost/timolol (BM/TM) in the treatment of ocular hypertension or glaucoma using a systematic review and metaanalyisis of randomized clinical trials (RCTs). METHODS: A systematic search for RCTs published between 2000 and 2009 was conducted in Medline, Embase and Controlled Trials Register databases. The outcome measured was the appearance of conjunctival hyperaemia in studies comparing the use of either LT/TM or BM/TM versus different therapeutic options. Statistical analysis was performed including the calculation of odds ratio (OR) and its respective confidence interval, along with the inter-trial statistical heterogeneity. A sensitivity analysis was also carried out. RESULTS: A total of 16 RCTs comparing LT/TM versus distinct therapeutic alternatives and 5 CT comparing BM/TM versus different therapeutic options fulfilled criteria to be included in the meta-analysis. Although heterogeneity of both comparisons was not very high in both the LT/TM group (Q = 24.47; p = 0.057; I2 = 38.7 %) and the BM/TM group (Q = 5.19; p = 0.268; I2 = 22.94 %), the estimation of the OR by the random effects model was considered the most appropriate. According to this model the final OR for the LT/TM group was 0.56 (IC95%: 0.37-0.83), p < 0.05 and for the BT/TM group the OR was 0.94 (IC95%: 0.66-1.34), p > 0.05. In the sensitivity analysis performed, none of the RCTs included in this meta-analysis had an important effect in the global estimation of OR. CONCLUSIONS: According to available data, the use of LT/TM is associated with a significant reduction in the development of conjunctival hyperaemia versus the comparators used in the RCTs, whereas the use of BM/TM produces a conjunctival hyperaemia rate similar to its comparators.
M.J. Vinuesa. Salamanca University, SalamancaSpain.
Classification:
11.13.4 Betablocker and prostaglandin (Part of: 11 Medical treatment > 11.13 Combination therapy)
2.1 Conjunctiva (Part of: 2 Anatomical structures in glaucoma)
