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Miscellaneous (31)

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Abstract #24727 Published in IGR 11-4

Effect of ferulic acid sodium on MDA, SOD of retina in rat models with chronic ocular hypertension

Zeng F; Li H
International Journal of Ophthalmology 2009; 9: 1668-1670

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AIM: To study the inhibition of ferulic acid sodium on retina oxidative damage in chronic ocular hypertension models. METHODS: Forty SD rats were randomly divided into three groups: blank control group, saline group and erulic acid sodium 5mg/kg, 10mg/kg group. We made a chronic ocular hypertension model, measured the intraocular pressure every day, and tested the maleic dialdehyde (MDA) content and superoxide dismutase(SOD) activity of retinal tissue 1, 3 days and 1, 2, 4 weeks after operation. RESULTS: The MDA and SOD were improved obviously after operation. The MDA content of blank control group and saline group had no significant change in the observation period. Ferulic acid sodium decreased a week after operation and was closed to nomal 4 weeks after operation. The SOD activity of blank control group and saline group decreased rapidly after a transient increase. Ferulic acid sodium group still declined significantly and maintained high level in the observation period. CONCLUSION: Ferulic acid sodium has protective effect on the oxidative stress in retina of chronic ocular hypertension models of rats. The protective effect can be achieved by eliminating oxygen free radical or protecting SOD activity. LA: Chinese

H. Li. Department of Ophthalmology, Nanhua University, Hengyang 421001, Hunan Province, China. lihong5056@yahoo.com.cn

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Classification:

5.1 Rodent (Part of: 5 Experimental glaucoma; animal models)
11.8 Neuroprotection (Part of: 11 Medical treatment)

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