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Abstract #25109 Published in IGR 12-1
Importance of the Nuclear Factor KappaB for the Primary Open Angle Glaucoma –a Hypothesis
Erb CKlinische Monatsblätter für Augenheilkunde 2010; 227: 120-127
The primary open-angle glaucoma (POAG) is an optic neuropathy which is influenced by a number of different risk factors. Some of them can induce the transcriptional factor NF-kappaB, a nuclear protein which binds to specific areas of the DNA to stimulate different genes. NF-kappaB can be activated by increased intraocular pressure, increased age, vascular diseases and by oxidative stress. In the case of POAG NF-kappaB might be overstimulated with the induction of uncontrolled biochemical reactions. Treatment strategies for reducing NF-kappaB are to reduce intraocular pressure as well as therapies with statins, omega-3-fatty acids and alpha-lipoic acid. This model is a hypothesis and is intende to provide a basis for further discussions and basic research.
Abteilung für Augenheilkunde, Schlosspark-Klinik.
Classification:
3.9 Pathophysiology (Part of: 3 Laboratory methods)
