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Abstract #25488 Published in IGR 12-1
Three novel polymorphic microsatellite markers for the glaucoma locus GLC1B by datamining tetranucleotide repeats on chromosome 2p12-q12
Murga-Zamalloa C; Guevara-Fujita M L; Estrada-Cuzcano A; Fujita RGenetics and Molecular Biology 2009; 32: 720-722
In order to identify new markers around the glaucoma locus GLC1B as a tool to refine its critical region at 2p11.2-2q11.2, we searched the critical region sequence obtained from the UCSC database for tetranucleotide (GATA)n and (GTCT)n repeats of at least 10 units in length. Three out of four potential microsatellite loci were found to be polymorphic, heterozygosity ranging from 64.56% to 79.59%. The identified markers are useful not only for GLC1B locus but also for the study of other disease loci at 2p11.2-2q11.2, a region with scarcity of microsatellite markers.
R. Fujita. Centro de Genetica Y Biologia Molecular, Facultad de Medicina, Universidad de San Martin de Porres, Alameda del Corregidor 1535, La Molina, Lima, Peru. rfujita@rcp.net.pe
Classification:
3.4.2 Gene studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)
