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Abstract #25533 Published in IGR 12-1
Long-term effects of prostaglandin analogues on the anterior chamber depth of patients with primary open-angle glaucoma
Simek S; Yulek F; Cakmak H B; Midillioglu N KCutaneous and Ocular Toxicology 2009; 28: 125-128
Objective: To evaluate the effect of long-term application of bimatoprost and latanoprost on the anterior chamber depth of primary open-angle glaucoma patients. Methods: The anterior chamber depth (ACD) and axial length (AL) of patients using prostaglandin analogues for open-angle glaucoma (group I) and an age- and gender-adjusted control group (group II) were measured by ultrasonography. Patients using bimatoprost and those using latanoprost were also compared in terms of ACD and AL. Results: The mean ACD of group I (27 eyes of 27 subjects) was significantly lower than that of group II (30 eyes of 30 subjects) (p=.012). Similarly, the ratio of ACD to AL was significantly lower in group I compared with group II (p=.001). The ACDs of patients using bimatoprost or latanoprost and the control group were not significantly different by Kruskal-Wallis test (p=.056), but the differences of these 3 groups in ACD/AL ratios were significant (p=.004). When the Mann Whitney U test was used for pairwise comparison, there was a significant difference between the control group and the patients using latanoprost or bimatoprost in terms of the ACD/AL ratio (p=.008 for each). There was no difference between the patients using latanoprost and those using bimatoprost in terms of the ACD/AL ratio (p=.4). Conclusion: The ACD of patients on prolonged therapy with prostaglandin analogues seems to be lower than than that of the control group. However, prospective long-term studies on large number of subjects are needed to evaluate the effect of each type of prostaglandin on ocular structures.
F. Yulek. Gulden Sokak, No: 13/1, Kavakldere, Ankara 06590, Turkey. fatmayulekt@yahoo.com
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
2.4 Anterior chamber angle (Part of: 2 Anatomical structures in glaucoma)
